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Importance of Circulating Platelet Aggregates and Haemodynamic Changes in Ophthalmic Artery and Progression of Visual Field Loss at Pseudoexfoliation Glaucoma

Veljko Rogošić
Lovro Bojić
Lucija Vanjaka Rogošić
Marina Titlić
Mladen Lešin
Željko Kovačić
Kolja Poljak
Darko Duplančić

Puni tekst: engleski pdf 70 Kb

str. 477-482

preuzimanja: 240



The aim of this work is to examine the role of circulating platelet aggregates (CPA) at pseudoexfoliation glaucoma
(PXG), haemodynamic changes in the ophthalmic artery by ultrasonic color Doppler, searching for visual field progression.
Vascular component at PXG and its role in VF progression dynamics has not been sufficiently explained, as well as
CPA influence to ischaemic events related to optic nerve damage and VF progression. The examination included 80 patients,
where of 35 (44%) men average age 68.3±7.0 and 45 (56%) women average age 65.7±7.0 (t=1.66; p=0.101). Forthy
of them suffered from primary open angle glaucoma (POAG) as a control group (healthy), and 40 from pseudoexfoliative
glaucoma (PXG) as an experimental group. All the examinees underwent complete ophthalmological examination: visual
acuity, ocular fundus, intraocular pressure measured, anterior eye segment biomicroscopy with gonioscopy performed.
Also VF examination was performed three times at 6 months intervals. Laboratory testing of CPA proportion values
was performed by means of Wu an Hoak method and ultrasonic measurement of blood perfusion in the carotid tree,
particularly concerning ophthalmic artery by means of color Doppler. Obtained decreased values of CPA proportion resulted
in hypercoagulability of blood in PXG group. At PXG were also found increased blood flow resistivity indexes in
ophthalmic artery (RI AO) and internal carotid artery (RI ACI), resulting with ischemia and hypoxia and finally progression
of the visual filed damage. In conclusion, our study shows that examining CPA and ultrasonic monitoring of
vascular parameters in ophthalmic artery with color Doppler may be the way of better understanding the vascular role in
PXG prognosis.

Ključne riječi

pseudoexfoliative glaucoma (PXG), primary open-angle glaucoma (POAG), circulating platelet aggregates (CPA), ophtalmic artery (OA), color doppler sonography (CDI), visual field (VF), optic nerve (ON), ocular blood flow (OBF)

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