Short communication, Note
Isolated intracranial sinus histiocytosis: Report of two cases with Rosai-Dorfman disease
Vili Beroš
; Clinics for neurosurgery, CHC Sisters of mercy, Zagreb
Karlo Houra
; Department of surgery, General hospital Zabok
Hrvoje Čupić
; Clinics for pathology, CHC Sisters of mercy, Zagreb
Darko Stipić
; Clinics for neurosurgery, CHC Sisters of mercy, Zagreb
Kamelija Žarković
; Clinics for pathology, CHC Zagreb
Krešimir Rotim
; Clinics for neurosurgery, CHC Sisters of mercy, Zagreb
Abstract
Aim: Rosai-Dorfman Disease (RDD) is an idiopathic histiocytic proliferation affecting lymph nodes. Rosai-Dorfman disease rarely affects intracranial structures without involvement of other sites. In this paper we are presenting two cases of RDD with isolated intracranial involvement. Case report: The first patient is a 39-year-old male presenting with an isolated well-circumscribed brain mass in the right temporal lobe, preoperatively thought to be a meningioma. Histological and immunohistochemical analysis confirmed that the lesion was RDD. The intraparenchymal brain location of RDD appears to have a benign course. We also describe the case of 41-year-old man presenting with vertiginous symptoms and mild cerebellar ataxia who was diagnosed with a solitary lesion localised deep in the right cerebellar hemisphere. Immunohistological findings also revealed Rosai-Dorfman disease. Discussion and conclusion: In this paper we are presenting the clinical features, tumor characteristics, differential diagnosis and treatment options. Thorough preoperative evaluation is mandatory and biopsy should be done whenever possible. Surgical treatment of this type of tumour is not always necessary, however, it is essential for postulating the right diagnosis. When total tumor removal is achieved, the outcome is generally better. Recurrence was not observed in our cases where total surgical excision was performed and there was no need for additional therapy. From the clinical point of view RDD might be an important intracerebral entity because it might mimic other lesions, particularly other histiocytic disorders.,îÿÀ
Keywords
central nervous system; intracerebral lesions; Rosai-Dorfman disease; surgery
Hrčak ID:
70143
URI
Publication date:
1.6.2011.
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