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Genetic analysis of 7 medieval skeletons from the Aragonese Pyrenees
Carolina Núńez
; Department of Forensic Medicine Faculty of Medicine, University of Zaragoza, Zaragoza, Spain
Cecilia Sosa
; Department of Forensic Medicine Faculty of Medicine, University of Zaragoza, Zaragoza, Spain
Miriam Baeta
; Department of Forensic Medicine Faculty of Medicine, University of Zaragoza, Zaragoza, Spain
Maria Geppert
; Department of Forensic Genetics Institute of Legal Medicine and Forensic Sciences, Charité-Universitätsmedizin, Berlin, Germany
Meredith Turnbough
; Department of Forensic and Investigative Genetics, University of North Texas Health Science Center, Denton, Tex, USA
Nicole Phillips
; Department of Forensic and Investigative Genetics, University of North Texas Health Science Center, Denton, Tex, USA
Yolanda Casalod
; Department of Forensic Medicine Faculty of Medicine, University of Zaragoza, Zaragoza, Spain
Miguel Bolea
; Department of Forensic Medicine Faculty of Medicine, University of Zaragoza, Zaragoza, Spain
Rhonda Roby
; Department of Forensic and Investigative Genetics, University of North Texas Health Science Center, Denton, Tex, USA
Bruce Budowle
; Institute of Investigative Genetics University of North Texas Health Science Center, Tex, USA
Begońa Martínez-Jarreta
; Department of Forensic Medicine Faculty of Medicine, University of Zaragoza, Zaragoza, Spain
Sažetak
Aim To perform a genetic characterization of 7 skeletons
from medieval age found in a burial site in the Aragonese
Pyrenees.
Methods Allele frequencies of autosomal short tandem
repeats (STR) loci were determined by 3 different STR systems.
Mitochondrial DNA (mtDNA) and Y-chromosome
haplogroups were determined by sequencing of the hypervariable
segment 1 of mtDNA and typing of phylogenetic
Y chromosome single nucleotide polymorphisms (YSNP)
markers, respectively. Possible familial relationships
were also investigated.
Results Complete or partial STR profiles were obtained in
3 of the 7 samples. Mitochondrial DNA haplogroup was
determined in 6 samples, with 5 of them corresponding
to the haplogroup H and 1 to the haplogroup U5a. Ychromosome
haplogroup was determined in 2 samples,
corresponding to the haplogroup R. In one of them, the
sub-branch R1b1b2 was determined. mtDNA sequences
indicated that some of the individuals could be maternally
related, while STR profiles indicated no direct family relationships.
Conclusions Despite the antiquity of the samples and
great difficulty that genetic analyses entail, the combined
use of autosomal STR markers, Y-chromosome informative
SNPs, and mtDNA sequences allowed us to genotype a
group of skeletons from the medieval age.
Ključne riječi
Hrčak ID:
71443
URI
Datum izdavanja:
15.6.2011.
Posjeta: 1.450 *