Croatica Chemica Acta, Vol. 84 No. 2, 2011.
Prethodno priopćenje
https://doi.org/10.5562/cca1948
Start/stop Codon-like Trinucleotides (CLTs) and Extended Clusters as New Language of DNA
Marija Rosandić
; Faculty of Science, University of Zagreb, Bijenička c. 32, HR-10000 Zagreb, Croatia
Matko Glunčić
; Faculty of Science, University of Zagreb, Bijenička c. 32, HR-10000 Zagreb, Croatia
Vladimir Paar
orcid.org/0000-0001-5349-9886
; Faculty of Science, University of Zagreb, Bijenička c. 32, HR-10000 Zagreb, Croatia
Sažetak
DNA nucleotide sequences carry genetic information of different kinds, not just coding instructions
for protein synthesis. They can play a role, for example, in alternative conformations and gene regulators.
The present paper introduces the extended start/stop codon-like trinucleotides (CLTs) for noncoding
DNA sequences, based on trinucleotide cluster extension generated by specific single-nucleotide multiplications.
Extended cluster analysis gives rise to rich information potential as a "new language" of DNA
("CLT-language"). The analysis of start/stop-CLTs extended clusters provides qualitative and quantitative
differentiation and characterization of alpha satellites, as well as of other repetitive and non-repetitive
noncoding sequences. As a measure of CLT extension of DNA sequences the extension factor r is introduced.
Start/stop CLTs enable a distinction of three segments within alpha satellite, the first and the
second as wrapping sequences and the third as a linker. Within a linker there are no start/stop CLTs. On
the basis of start/stop-CLTs, it is hypothesized that these noncoding sequences may be involved in the
networks of gene regulators. (doi: 10.5562/cca1948)
Ključne riječi
alpha satellites; start/stop codons; nucleosome; cluster extension; gene regulators
Hrčak ID:
71995
URI
Datum izdavanja:
3.10.2011.
Posjeta: 2.233 *