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Transplantation of Amniotic Membrane in Corneal Ulcers and Persistant Epithelial Defects

Renata Gržetić-Lenac
Maja Merlak
Tihomir Balog
Marijana Bilen Babić
Iva Dekaris

Puni tekst: engleski pdf 61 Kb

str. 167-169

preuzimanja: 440



Amniotic membrane transplantation (AMT) leads to reduction of inflammatory symptoms and causes faster epithelisation
in corneal ulcers and persistant epithelial defect. 21 patients with corneal ulcer (n=18) or non-healing epithelial
defect (n=3) unresponsive to conventional treatment were included in the study. All patients were treated by AMT.
Corneal epithelial cells in patients suffering from corneal ulcer secreted 3.51±1.79 of IL-1a, 64.27±31.53 pg/mL of TNFa
and 209.07±201.82 pg/mL of VEGF. Levels of all 3 investigated cytokines were significantly higher as compared to controls
(p<0.005). Amniotic membranes that were used contained 775.69±613.98 pg/mL of IL-1ra, 0.036±0.033 pg/mL of
sTNF and 175.01±166.63 pg/mL of VEGF-R. Supporting effect of the AMT could be explained by the fact that AM secretes
its natural antinflammatory antagonists IL-1ra, sTNF and VEGF-R.

Ključne riječi

amniotic membrane transplantation; corneal ulcer; persistent epithelial defects; cytokines

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