Izvorni znanstveni članak

Hemoglobin Hasharon and Hemoglobin NYU in subjects of German origin

Berndt Zur ; Department of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn, Germany
Michael Ludwig ; Department of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn, Germany
Birgit Stoffel-Wagner ; Department of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn, Germany

Sažetak

Determination of HbA1c values with high performance liquid chromatography (HPLC) occasionally reveals hemoglobin anomalies with no or minimal clinical evidence. We coincidentally detected two cases of Hb Hasharon, an alpha globin gene mutation, in two heterozygous patients and one case of Hb NYU, a delta globin gene mutation, in another patient. Both anomalies have not been described in subjects of German origin to date. Characterization was carried out with HPLC, hemoglobin electrop-horesis, capillary zone electrophoresis, DNA sequencing, complete blood count and clinical chemical analysis.

Ključne riječi

Hb Hasharon; Hb NYU; German origin; HbA1c screening

Hrčak ID:

72954

URI

https://hrcak.srce.hr/72954

Datum izdavanja:

15.10.2011.

Posjeta: 1.912 *