Veterinarski arhiv, Vol. 73. No. 3, 2003.
Izvorni znanstveni članak
Serum biochemical changes in experimental Trypanosoma congolense and Trypanosoma brucei infection in Small East Africa goats.
Savino Biryomumaisho
; Department of Veterinary Medicine, Makerere University, Kampala, Uganda
Eli Katunguka-Rwakishaya
; Department of Veterinary Medicine, Makerere University, Kampala, Uganda
C. M. Rubaire-Akiiki
; Department of Veterinary Parasitology and Microbiology, Makerere University, Kampala, Uganda
Sažetak
Serum biochemical changes in goats challenged with either Trypanosoma congolense or Trypanosoma brucei and uninfected controls were investigated. Experimental goats received a primary trypanosome challenge on day 0, treated with diminazene aceturate on day 49 and received a secondary trypanosome challenge on day 77 of the 136-day experiment. Infection was associated with development of anaemia, hypoproteinaemia, hypoalbuminaemia, hypocholesteraemia, low density and high density hypolipidaemia. In both the primary and secondary challenges, however, serum free fatty acid concentrations were significantly higher than those of the controls. These changes suggest that the growing numbers of trypanosomes post-infection in goats require some lipids and proteins to support their growth, while the higher free fatty acid concentration observed may directly contribute to the development of anaemia as free fatty acids are known to be potentially cytotoxic and haemolytic in vitro.
Ključne riječi
goats; serum proteins; lipids; trypanosomosis
Hrčak ID:
74864
URI
Datum izdavanja:
22.6.2003.
Posjeta: 1.203 *