Medicina Fluminensis, Vol. 47 No. 4, 2011.
Pregledni rad
Adult acute myeloid leukemia: diagnosis and treatment
Lana Grković
; Zavod za hematologiju, Klinika za unutarnje bolesti, KBC Zagreb, Zagreb
Boris Labar
; Zavod za hematologiju, Klinika za unutarnje bolesti, KBC Zagreb, Zagreb
Sažetak
Acute myeloid leukemia (AML) is a heterogeneous clonal disorder of hematopoietic progenitor cells. AML is a disease of elderly people with the median age of presentation being 67 years. In the past few years, research in molecular biology has lead to a better understanding of the disease pathophysiology. Genetic abnormalities are one of the most important factors which determine the disease outcome and response to chemotherapy, and their better understanding is needed for development of new treatment approaches. Although significant advances have been made in treatment of younger patients, results of the treatment in the elderly is still unsatisfactory. Current clinical trials are focused on target therapy development.
Ključne riječi
acute myeloid leukemia; genetic abnormalities; survival; treatment
Hrčak ID:
76664
URI
Datum izdavanja:
1.12.2011.
Posjeta: 11.935 *