Izvorni znanstveni članak

Pharmacokinetics and optimal dosage of kanamycin in domestic ruminant species.

Ijaz Javed ; Department of Physiology and Pharmacology, Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan
Muhammad Nawaz ; Department of Physiology and Pharmacology, Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan
Faqir Hussain Khan ; Department of Physiology and Pharmacology, Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan

Sažetak

Pharmacokinetics and optimal dosage of kanamycin were investigated in domestic ruminant species. In indigenous female adult Nili/Ravi buffaloes, Sahiwal cattle, Lohi sheep and Teddy goats, values of elimination half-life (t1/2β)volume of distribution (Vd) and total body clearance (ClB) have been found to be greater than most respective values in their foreign counterparts. Elimination halflife values in domestic ruminants correspond to their respective glomerular filtration rate (GFR) values: the higher the GFR, the shorter the half-life. Comparison of half-life values in domestic ruminants with corresponding total body clearance values showed that shorter half-life should not be equated with higher clearance. To maintain the minimum inhibitory concentration (MIC) of 2 μg/ml of plasma, an optimal dosage regimen of 10.9, 10.2, 12.7 and 15.4 mg/kg body mass for priming and 9.31, 7.79, 11.7 and 14.7 mg/kg body mass for maintenance to be repeated at 12 hour interval have been suggested in buffaloes, cattle, sheep and goats, respectively.

Ključne riječi

kanamycin; pharmacokinetics; dosage; domestic ruminants

Hrčak ID:

76727

URI

https://hrcak.srce.hr/76727

Datum izdavanja:

21.12.2003.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.827 *