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CORRELATION OF PRE-MORBID ALCOHOLISM AND CHANGES IN THE LEVEL OF BIOGENIC AMINE METABOLITES IN CEREBROSPINAL FLUID OF ACCUTE BRAIN INFARCTION PATIENTS

Milutin Nenadović ; Special Psychiatric Hospital Laza Lazarević, Belgrade, Serbia
Sreten Vićentić ; Department of Psychiatry, General Hospital, Šabac, Serbia
Nenad Nenadović ; Military Medical Academy, Belgrade, Serbia
Miroslava Jašović-Gašić ; Clinic of Psychiatry, Clinical Center of Serbia, Belgrade, Serbia

Sažetak

Background: The disorder of biogenic amine metabolism (serotonin – 5-HT and dopamine – DA) is expected in the brain (neuron)
damage caused by acute ischemia. It is known that long-term abuse of ethyl-alcohol damages the quality of neurons diffusely in the
brain. Cerebrospinal fluid (CSF) and its biochemical content, 5-HT and DA, are reliable indicators of the vitality of neurons.
The main objective of this research was to demonstrate that the elevated content of metabolites 5-HT and DA in the CSF in
patients with acute brain infarction, who were pre-morbid alcohol-dependent patients, is additionally emphasized by diffusive
damage of neuron vitality caused by alcoholism.
Subjects and methods: Study sample consists of two groups - 50 alcohol-dependent patients with acute brain infarction under
the age of 65 (group A) and 50 patients with acute brain infarction who were not alcohol-dependent (group B). All subjects
underwent the same procedure - CSF was taken during admission to the hospital and history was obtained through anamnesis,
heteroanamnesis and clinical examinations.
Results: Metabolism of DA and metabolic turnover of DA (3, 4 dihydroxyphenylacetic acid + homovanilic acid; DOPAC +
HVA) was elevated in the liquor of both patient groups. The statistically significant difference between the groups was found in
metabolic turnover of 5-HT (p<0.05), and metabolic turnover of DA (p<0.001).
Conclusions: The metabolic neuron disbalance, i.e. their pathophysiological-biochemical dysfunction as a result of acute brain
infarction, is present in a higher degree in patients with pre-morbid long-term alcohol abuse.

Ključne riječi

erebrospinal fluid (CSF); biogenic amines in CSF; dopamine in CSF; serotonin metabolites in CSF; alcoholism and brain infarction

Hrčak ID:

76813

URI

https://hrcak.srce.hr/76813

Datum izdavanja:

30.6.2011.

Posjeta: 734 *