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Blood lactate levels in patients receiving first- or secondgeneration antipsychotics

Trpimir Glavina ; Psychiatric Clinic, Split Clinical Hospital Center, Split, Croatia
Damir Mrass ; Psychiatric Clinic, Split Clinical Hospital Center, Split, Croatia
Tajana Dodig ; Vrapče Psychiatric Hospital, Zagreb, Croatia
Gordana Glavina ; Clinical Institute of Radiology Split Clinical Hospital Center, Split, Croatia
Shelly Pranić ; University of Split School of Medicine, Split, Croatia

Puni tekst: engleski pdf 237 Kb

str. 41-47

preuzimanja: 488



Aim To compare the blood lactate levels between patients
with psychotic disorder receiving first- and those receiving
second-generation antipsychotics.
Methods The study was conducted at the psychiatric inpatient
and outpatient clinics of the Split Clinical Hospital
from June 6, 2008 to October 10, 2009. Sixty patients with
psychotic disorder who were assigned to 6-month treatment
were divided in two groups: 30 received haloperidol
(first generation antipsychotic) and 30 received olanzapine
(second generation antipsychotic). Blood lactate levels,
other metabolic parameters, and scores on the extrapyramidal
symptom rating scale were assessed.
Results Patients receiving haloperidol had significantly
higher blood lactate levels than patients receiving olanzapine
(P < 0.001). They also more frequently had parkinsonism,
which was significantly correlated with both haloperidol
treatment at 1 month (P < 0.001) and 6 months
(P = 0.016) and olanzapine treatment at baseline (P = 0.016),
3 months (P = 0.019), and 6 months (P = 0.021). Also, patients
receiving haloperidol had significant correlation between
blood lactate and dystonia at 1 month (P < 0.001)
and 6 months (P = 0.012) and tardive dyskinesia at 1 month
(P = 0.032). There was a significant difference between the
treatment groups in lactate levels at all points from baseline
to month 6 (P < 0.001).
Conclusion It is important to be aware of the potential effect
of haloperidol treatment on increase in blood lactate
levels and occurrence of extrapyramidal side effects. Therefore,
alternative antipsychotics should be prescribed with
lower risk of adverse side effects.
Trial identification number: NCT01139463

Ključne riječi

antipsychotics; lactates; side effects

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