Acta clinica Croatica, Vol. 50 No. 2, 2011.
Izvorni znanstveni članak
White Blood Cell Count in Different Stages of Chronic Periodontitis
Ana Pejčić
Ljiljana Kesić
Zoran Pešić
Dimitrije Mirković
Mariola Stojanović
Sažetak
Periodontal disease is considered to be an inflammatory disorder that is related to the accumulation of oral microbial biofilm and the host response to this accumulation. The host reaction to gingival microorganisms is characterized in part by increase in the polymorphonuclear leukocyte counts, which is one of the most important steps in host defense. Exaggerated leukocytes and neutrophils of host response are a very important component in the pathogenesis of periodontal disease. The purpose of this study was to investigate the relationship between white blood cell count and periodontal disease in subjects with moderate and severe periodontitis and in control subjects with healthy periodontal tissues. Leukocytes for the present study were obtained from peripheral venous blood of 50 patients with moderate periodontitis, 50 patients with severe periodontitis and 25 healthy subjects. The clinical parameters of periodontitis including plaque index, bleeding on probing and gingival index were determined in all study subjects. In both moderate and severe periodontitis, the results indicated a significantly higher count of neutrophils (p<0.001), as well as of both lymphocytes and total leukocytes (p<0.05). The values of clinical parameters (plaque index, gingival index and bleeding on probing) also showed significant between-group differences (p<0.005 and p<0.001, respectively). It is possible that there is a significant relationship between total leukocyte count, neutrophil count and different forms of periodontal disease.
Ključne riječi
Chronic periodontitis; Leukocytes; Neutrophils; Inflammation
Hrčak ID:
79303
URI
Datum izdavanja:
28.6.2011.
Posjeta: 4.272 *