Veterinarski arhiv, Vol. 72 No. 6, 2002.
Izvorni znanstveni članak
Growth rate of bones in rat foetal alcohol syndrome.
Innocent Chima Nwaogu
; Department of Veterinary Anatomy, Faculty of Veterinary Medicine, University of Nigeria Nsukka, Enugu State, Nigeria
Sažetak
The effect of maternal alcohol consumption during pregnancy on the growth rate of humerus and femur were studied in 168 offspring of rats. Experimental foetal alcohol syndrome was produced by giving 10% ethanol (v/v) in water to eight-week-old female albino rats for 2 weeks, then 20% ethanol (v/v) for a further 3 weeks, and mating them overnight. When confirmed pregnant, the alcohol concentration was increased to 30% until delivery, when alcohol consumption was stopped. The control group was not given alcohol and both groups were fed ad libitum. Birth masses, as well as lengths of humerus and femur, of the control rats were significantly higher (P<0.01) than those of pre-natally alcohol-exposed rats at 3, 5, 7, 9, 11 and 14 weeks of age. There was no significant difference (P>0.05) between litter sizes of both groups. The relative growth rates of femur were significantly higher (P<0.01) in the experimental group than in the control group. These results suggest that the low birth masses observed in pre-natally alcohol-exposed rats did not depend on litter size. They also demonstrated that alcohol consumption by pregnant rats adversely affected the growth rates of humerus and femur of their offspring pre-natally, and this effect persisted throughout the period of this study.
Ključne riječi
albino rat; alcohol; bones; foetus; growth rate
Hrčak ID:
81607
URI
Datum izdavanja:
18.12.2002.
Posjeta: 1.120 *