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https://doi.org/10.2478/v10007-012-0021-2

Porous nanoparticles of metoprolol tartrate by spray-drying: Development, characterization and in vitro evaluation

MOHAMMED S. KHAN ; Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagara,
GOWDA D. VISHAKANTE ; Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagara,
HOSAKOTE G. SHIVAKUMAR ; Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagara,


Puni tekst: engleski pdf 163 Kb

str. 383-394

preuzimanja: 801

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Sažetak

The present investigation was undertaken to fabricate porous nanoparticles of metoprolol tartrate by spray-drying using ammonium carbonate as pore former. Prepared nanoparticles were coated with Eudragit S100 polymer in order to prevent the release of metoprolol tartrate in the upper GI tract. It was shown that nanoparticles with low size ranges can be obtained with a low feed inlet rate. Micromeritic studies confirmed that nanoparticle batches are discrete and free flowing. Effects of the pore former on drug loading, porosity and in vitro release were studied. It was found that there was an increase in drug loading and porosity with increased the amount of pore former. In vitro drug release studies showed that an increase in pore former made drug release faster. Release kinetics proved that nanoparticles follow a zero-order release mechanism.

Ključne riječi

metoprolol tartrate; porous nanoparticles; spray drying; gel permeation chromatography

Hrčak ID:

81771

URI

https://hrcak.srce.hr/81771

Datum izdavanja:

30.9.2012.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.940 *