Acta Pharmaceutica, Vol. 62 No. 3, 2012.
Izvorni znanstveni članak
https://doi.org/10.2478/v10007-012-0025-y
Ciljana isporuka budezonida u kolonu iz trostruko obloženih peleta: In vitro/in vivo evaluacija
JALEH VARSHOSAZ
; Department of Pharmaceutics, Faculty of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
JABER EMAMI
; Department of Pharmaceutics, Faculty of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
NASER TAVAKOLI
; 1Department of Pharmaceutics, Faculty of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
MOHSEN MINAIYAN
; Department of Pharmacology, Faculty of Pharmacy and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
NAKISA RAHMANI
; Department of Pharmaceutics, Faculty of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
FARID DORKOOSH
; Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
PARVIN MAHZOUNI
; Department of Clinical Pathology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Sažetak
U radu je opisana priprava troslojnih peleta budezonida za ciljanu isporuku u kolonu metodom ekstruzije-sferonizacije. Obložni slojevi sastojali su se od hidroksipropilmetilceluloze (HPMC) (barijerni sloj), Eudragita E (kontrolni sloj) i hidroksipropilmetilceluloze acetat sukcinata (HPMC AS) (crijevni sloj). Sloj koji kontrolira oslobađanje je dalje modificiran koristeći različite tvari koje stvaraju pore. Oslobađanje je proučavano pri pH 1,2, 7,4 i 6,8. Sastav jezgre pelete, te vrsta i količina tvari koje stvaraju pore utjecale su na oslobađanje lijeka iz peleta. Pelete koje u jezgri sadrže 20 % (m/m) limunske kiseline obložene s HPMC (6 %, m/m), Eudragit E s Avicelom RC 581 kao tvari za stvaranje pora (30 %, m/m) i HPMC AS (15 %, m/m) imale su najbolji profil oslobađanja. Pelete su pokazale dobre rezultate u eksperimentalnom modelu kolitisa u štakora induciranog trinitrobenzensulfonskom kiselinom.
Ključne riječi
isporuka u kolonu; troslojne pelete; Eudragit E; budezonid; HPMC AS; HPMC
Hrčak ID:
81776
URI
Datum izdavanja:
30.9.2012.
Posjeta: 2.405 *