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Croatian Medical Journal, Vol. 53 No. 1, 2012.

Original scientific paper

The influence of tumor necrosis factor microsatellite polymorphisms on patient survival following hematopoietic stem cell transplantation

Katarina Štingl orcid id orcid.org/0000-0003-4145-7405 ; Clinical Department for Transfusion Medicine and Transplantation Biology, University Hospital Center Zagreb, Zagreb Croatia
Renata Žunec ; Clinical Department for Transfusion Medicine and Transplantation Biology, University Hospital Center Zagreb, Zagreb Croatia
Ranka Serventi-Seiwerth ; Department of Hematology, Internal Clinic, University Hospital Center Zagreb, Zagreb, Croatia
Boris Labar ; Department of Hematology, Internal Clinic, University Hospital Center Zagreb, Zagreb, Croatia
Zorana Grubić ; Clinical Department for Transfusion Medicine and Transplantation Biology, University Hospital Center Zagreb, Zagreb Croatia

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Abstract

Aim To investigate the influence of tumor necrosis factor
(TNF) microsatellite polymorphisms on patient survival following
hematopoietic stem cell transplantation.
Methods We analyzed TNFa, TNFb, and TNFd microsatellites
among 100 patients who underwent allogeneic hematopoietic
stem cell transplantation from a human leukocyte
antigen (HLA)-identical sibling donor at the Internal
Clinic of the University Hospital Center Zagreb in the period
2001-2009. The analysis was performed using polymerase
chain reaction amplification and electrophoresis
on a polyacrylamide gel in an automated sequencer.
Results There was no significant difference in patient survival
with respect to the allele length at a given microsatellite.
However, a significantly lower survival rate was noticed
among patients who were positive for TNFa8 allele
(P < 0.001) and a significantly higher survival rate among
those who were positive for TNFa10 allele (P = 0.0220).
Conclusion These results for the first time suggest an influence
of TNFa microsatellite on patient survival following
HSCT and indicate a need for further studies of this microsatellite.

Keywords

Hrčak ID:

82890

URI

https://hrcak.srce.hr/82890

Publication date:

15.2.2012.

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