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https://doi.org/10.5562/cca1811

Effects of Oxime K203 and Oxidative Stress in Plasma of Tabun Poisoned Rats

Suzana Berend orcid id orcid.org/0000-0002-7710-8250 ; Institute for Medical Research and Occupational Health, Ksaverska c. 2, P.O. Box 291, 10000 Zagreb, Croatia
Ana Lucić Vrdoljak ; Institute for Medical Research and Occupational Health, Ksaverska c. 2, P.O. Box 291, 10000 Zagreb, Croatia
Kamil Musilek ; Department of Toxicology, Faculty of Military Health Sciences, University of Defense, Třebešská 1575, Hradec Králové, Czech Republic;Department of Chemistry, Faculty of Sciences, J.E. Purkinje University, Usti nad Labem, Czech Republic
Kamil Kuča ; Department of Toxicology, Faculty of Military Health Sciences, University of Defense, Třebešská 1575, Hradec Králové, Czech Republic;Department of Chemistry, Faculty of Sciences, J.E. Purkinje University, Usti nad Labem, Czech Republic;Center of Advanced
Božica Radić ; Institute for Medical Research and Occupational Health, Ksaverska c. 2, P.O. Box 291, 10000 Zagreb, Croatia


Puni tekst: engleski pdf 2.731 Kb

str. 193-199

preuzimanja: 862

citiraj


Sažetak

The highly toxic nature of tabun has been known for many years, but there are still serious limitations
to antidotal therapy. In this study, we used rats as an experimental model to evaluate the efficiency
of bispyridinium para-oxime K203 as therapy against tabun poisoning as well as to examine if induction
of oxidative stress is linked to organophosphate toxicity. K203 showed high potency in counteracting
tabun poisoning. Either alone or in combination with atropine, this oxime significantly increased cholinesterase
activity at 0.5 and 1 h compared to untreated rats poisoned with tabun. Simultaneous measurements
of markers of oxidative stress (lipid peroxidation and superoxide dismutase) showed that tabun poisoning,
but also therapy (oxime alone or oxime plus atropine) applied immediately after tabun poisoning, could
generate free radical species that may cause oxidative stress in rats. (doi: 10.5562/cca1811)

Ključne riječi

tabun, therapy, K203, cholinesterase, lipid peroxidation, superoxide dismutase

Hrčak ID:

84534

URI

https://hrcak.srce.hr/84534

Posjeta: 1.338 *