Izvorni znanstveni članak
Alterations in the Masseter Muscle and Plasma IL-6 Level Following Experimentally Induced Occlusal Interference and Chronic Stress – A Study in Rats
Sunčana Simonić-Kocijan
Ivone Uhač
Petra Tariba
Vesna Fugošić
Daniela Kovačević Pavičić
Vlatka Lajnert
Vedrana Braut
Sažetak
This study was undertaken to examine the alteration of masseter and plasma interleukin-6 after inducing occlusal
interference and chronic stress. Male Wistar rats were submitted to chronic stress procedure, exposed to occlusal interference,
or exposed to both mentioned procedures. Whole blood and masseter tissue were collected to determine interleukin-6
level, measured by means of ELISA. Masseter pain was evaluated using the orofacial formalin test. Masseter interleukin-
6 level was significantly higher in animals submitted to combination of occlusal interference and chronic stress
than in the control group (p<0.05). There was positive and significant correlation between pain response and masseter
interleukin-6 level (r=0.5741; p<0.0003). No significant differences in plasma interleukin-6 level were found between
groups (p>0.05), as well as no correlation with pain (p>0.05). Combination of occlusal interference and chronic stress
leads to strong local reaction characterized by high levels of masseter interleukine-6. High concentrations of muscle
interleukin-6 and its correlation with pain point to inflammatory background of masticatory muscle pain.
Ključne riječi
dental occlusion; interleukin-6; masseter muscle; orofacial pain; stress; psychological
Hrčak ID:
84943
URI
Datum izdavanja:
10.7.2012.
Posjeta: 1.186 *