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The Role of nm23 Gene in Colorectal Carcinogenesis

Andro Tripković
Ingrid Tripković
Snježana Tomić
Ana Kovačić
Leo Grandić
Vesna Čapkun


Puni tekst: engleski pdf 216 Kb

str. 43-48

preuzimanja: 581

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Sažetak

The aim of this study was to investigate the correlation of immunohistochemical expression of nm23 gene in colorectal cancer cells with tumor stage according to Dukes, tumor differentiation, occurrence of distant metastases and patient survival. This retrospective study included 100 colorectal cancer patients who underwent surgical treatment. Both pathological and clinical data were analyzed according to sex, age, immunohistochemical expression of nm23, tumor stage, tumor differentiation, occurrence of distant metastases and patient survival. Overexpression of nm23 gene was related to both good tumor differentiation and Dukes’ stage A, whereas no significant correlation was found between the occurrence of metastases and nm23 gene expression. There was no significant correlation between nm23 gene expression and 5-year survival of colorectal cancer patients either. Although the results of this study suggested that higher expression of nm23 gene correlated with an early stage of tumor and its good differentiation, this parameter cannot yet be taken as an independent and reliable prognostic indicator in colorectal cancer.

Ključne riječi

Colorectal cancer; nm23 gene; Tumor suppressor genes; Dukes’ stage; Metastases

Hrčak ID:

85734

URI

https://hrcak.srce.hr/85734

Datum izdavanja:

30.3.2012.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.412 *