Izvorni znanstveni članak
Body composition and serum levels of adiponectin, vascular endothelial growth factor, and interleukin-6 in patients with rheumatoid arthritis
Sergey P. Oranskiy
; Kuban State Medical University, Krasnodar, Russian Federation
Ludmila N. Yeliseyeva
; Kuban State Medical University, Krasnodar, Russian Federation
Anna V. Tsanaeva
; Kuban State Medical University, Krasnodar, Russian Federation
Nadezhda V. Zaytseva
; Kuban State Medical University, Krasnodar, Russian Federation
Sažetak
Aim To investigate differences in body composition and
body mass index (BMI) in patients with rheumatoid arthritis
(RA) and their correlations with serum production of
adiponectin, interleukin-6 (IL-6), and vascular endothelial
growth factor (VEGF).
Methods The study included 83 patients (age 53 ± 5 years)
with RA treated with methotrexate. We determined their
BMI, fat mass, and fat-free mass using bioimpedance analysis,
and serum concentrations of adiponectin, VEGF, and
IL-6 using immunoassay analysis.
Results Normal BMI was found in 39 (47%), overweight and
obesity in 26 (31%), and underweight in 18 (22%) patients.
Concentration of adiponectin was lower in overweight/
obese patients than in patients with normal BMI (2.1 [0.8-
3.9] μg/mL vs 8.9 (7.2-11.3) μg/mL). In underweight patients,
it was moderately increased (12.7 [9.3-14.8] μg/mL)
and the correlation between the concentrations of adiponectin
and IL-6 was positive (r = 0.4; P = 0.01). Concentrations
of VEGF and IL-6 were increased in all groups with
RA. The overweight/obese group showed a negative correlation
between the concentrations of adiponectin and
VEGF (r = - 0.34; P = 0.04), a positive correlation between
VEGF concentration and fat mass (r = 0.39; P = 0.02), and a
negative correlation between adiponectin concentration
and fat mass (r = - 0.23; P = 0.02).
Conclusion Inflammatory and angiogenesis activation
was found in RA patients with all types of body composition,
but only in those with obesity and overweight there
was a direct antagonism between adiponectin and VEGF.
Further research is needed to identify possible regimens of
metabolic correction in different variations of body composition.
Ključne riječi
Hrčak ID:
86019
URI
Datum izdavanja:
15.8.2012.
Posjeta: 1.027 *