Skoči na glavni sadržaj

Arhiv za higijenu rada i toksikologiju, Vol. 63 No. 3, 2012.

Izvorni znanstveni članak

https://doi.org/10.2478/10004-1254-63-2012-2179

Combined Effects of Cadmium and Decabrominated Diphenyl Ether on Thyroid Hormones in Rats

Marijana Ćurčić ; Department of Toxicology “Akademik Danilo Soldatović”, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Saša Janković ; Institute of Meat Hygiene and Technology, Belgrade, Serbia
Vesna Jaćević ; Poison Control Center, Military Medical Academy, Belgrade, Serbia
Sanja Stanković ; Department of Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Slavica Vučinić ; Poison Control Center, Military Medical Academy, Belgrade, Serbia
Ksenija Durgo ; Department for Biochemical Engineering, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia
Zorica Bulat ; Department of Toxicology “Akademik Danilo Soldatović”, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Biljana Antonijević ; Department of Toxicology “Akademik Danilo Soldatović”, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia

Puni tekst: engleski pdf 81 Kb

str. 255-261

preuzimanja: 873

citiraj

Sažetak

The aim of this study was to see how a mixture of cadmium (Cd) and decabrominated diphenyl ether (BDE209) affect thyroid function, namely thyroid-stimulating hormone (TSH), thyroxin (T4), free thyroxin (FT4), triiodothyronin (T3), and free triiodothyronin (FT3) in Wistar rats (eight per group) receiving either a single substance or their combination by gavage for 28 days. Three groups were receiving Cd alone in the doses of 2.5 mg kg-1, 7.5 mg kg-1, or 15 mg kg-1 b. w. a day, three groups were receiving BDE209 in the doses of 1000 mg kg-1, 2000 mg kg-1, or 4000 mg kg-1 b. w. a day, while nine groups were receiving different mixtures of Cd and BDE209 in these doses (3x3 design). The results have indicated that the Cd+BDE209 mixtures more potently disrupt thyroid hormone homeostasis than would be expected from these chemicals alone.

Ključne riječi

BDE209; Cd; thyroid-stimulating hormone; thyroxin; triiodothyronin

Hrčak ID:

86882

URI

https://hrcak.srce.hr/86882

Datum izdavanja:

25.9.2012.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.093 *