Izvorni znanstveni članak
Nucleation Kinetics of Cis-Entacapone
D. Škalec Šamec
; PLIVA Croatia Ltd., Prilaz baruna Filipovića 25, 10000 Zagreb, Croatia
E. Meštrović
; PLIVA Croatia Ltd., Prilaz baruna Filipovića 25, 10000 Zagreb, Croatia
A. Sander
orcid.org/0000-0002-7477-3052
; University of Zagreb, Faculty of Chemical Engineering and Technology, Marulićev trg 20, 10000 Zagreb, Croatia
Sažetak
The solubility curve and the metastable zone width for the system cis-entacapone –2-propanol have been determined in defined process conditions. These results along with values of induction period for the constant feed concentration at different levels of
supersaturation were used for evaluating interfacial energy according to the classical nucleation theory. The results obtained were used for calculation of the critical nucleus size, nucleation rate, and prediction of crystal growth mechanism. Solubility data and metastable zone width determines the way to achieve the essential
supersaturation level, as well as provides information necessary for control of the crystallization process. Knowledge of the fundamental parameters of nucleation kinetics led to the better understanding of the crystallization process in order to obtain a product with desired solid state characteristics.
Ključne riječi
Crystal growth; entacapone; induction period; metastable zone width; nucleation; solubility
Hrčak ID:
87348
URI
Datum izdavanja:
3.10.2012.
Posjeta: 1.008 *