Ostalo
Association of Tumor Necrosis Factor α (TNF-α) and Interleukin 10 (IL-10) Gene Polymorphisms in Dermatomyositis Patients: A Pilot Study
Maria Hrisova
; Department of Dermatology and Venereology Sofia Medical University 1 Georgi Sofijski Street 1431 Sofia Bulgaria
Lyubomir Dourmishev
Zornitsa Kamenarska
Radka Kaneva
Anton Vinkov
Vanio Mitev
Sažetak
TNF-α and IL-10 single nucleotide polymorphisms have
been implicated in various autoimmune diseases but the results are
still quite controversial. This case-control study aimed to investigate
the association between six TNF-α and five IL-10 polymorphisms
with dermatomyositis. The -857CC and +489GG genotypes showed
a weak association with dermatomyositis when the analysis was carried
out for the whole cohort but they appeared to be a significant
risk factor for the development of dermatomyositis in women. The
TNF-α -1031CC genotype was found only among dermatomyositis
patients. The TNF-α -1031C/-863C/-857C-308G/+489G haplotype
showed a significant association with dermatomyositis in women.
The IL-10 -3575TT genotype and T allele showed an association with
dermatomyositis. The frequency of the IL-10 -2763CC genotype and
C allele was higher among dermatomyositis patents and it was associated
with an increased OR. Haplotype analysis showed an association
between the IL-10 -3575T/-2763C haplotype and dermatomyositis.
In conclusion, our results indicate that both TNF-α and
IL-10 polymorphisms are associated with the development of dermatomyositis
in Bulgarian patients.
Ključne riječi
TNF-α; IL-10; gene polymorphisms; dermatomyositis
Hrčak ID:
89114
URI
Datum izdavanja:
14.10.2012.
Posjeta: 502 *