Uvodnik

PATHOPHYSIOLOGICAL MECHANISMS OF ALLERGIC DISEASE OCCURRENCE AND TREATMENT

BRANKO PEVEC ; Odjel za kliničku imunologiju, pulmologiju i reumatologiju,Klinička bolnica “Sveti Duh”, Zagreb, Hrvatska
MIRA RADULOVIĆ PEVEC ; Odjel za kliničku imunologiju, pulmologiju i reumatologiju,Klinička bolnica “Sveti Duh”, Zagreb, Hrvatska
ASJA STIPIĆ MARKOVIĆ ; Odjel za kliničku imunologiju, pulmologiju i reumatologiju,Klinička bolnica “Sveti Duh”, Zagreb, Hrvatska
IRENA BATIŠTA ; Imunološki laboratorij,Klinička bolnica “Sveti Duh”, Zagreb, Hrvatska

Sažetak

Why the exposure to the harmless and ubiquitous environmental substances causes inappropriately strong reactions of the immune
system clinically manifested as allergies in some people, and how repeated exposures to the same substances during the
specific immunotherapy divert immunologic reactivity, are so far only partially answered questions. The events that occur during the allergic inflammatory response are relatively well-known, as are the major operative mechanisms through which the specific
immunotherapy, the only causative treatment method, change that response. Nevertheless, everyday new findings are completing
the puzzle and our understanding of these complex processes. The aim of this paper was to review the up-to-date known mechanisms of allergic disease occurrence and treatment, with regard to the key role of T cells in these processes.

Ključne riječi

allergy; specific immunotherapy; T cells; Treg; Th1; Th2; T-BET; GATA-3; FOXP3

Hrčak ID:

89626

URI

https://hrcak.srce.hr/89626

Datum izdavanja:

30.10.2012.

Podaci na drugim jezicima: hrvatski

Posjeta: 4.844 *