Veterinarski arhiv, Vol. 70. No. 3, 2000.
Izvorni znanstveni članak
Antigenic variation among Nigerian strains of equine H3 influenza viruses.
Christopher Adeyinka Olugbenga Adeyefa
; Department of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria; Institute for Animal Health, Pirbright Laboratory, Pirbright, United Kingdom
John William McCauley
; Institute for Animal Health, Pirbright Laboratory, Pirbright, United Kingdom
Tomori Oyewale
; Department of Virology, College of Medicine, University of Ibadan, Ibadan, Nigeria
Sažetak
Antigenic variation among three recent isolations of equine-2 H3N8 influenza viruses from Ibadan, Nigeria is reported. Antigenic analysis with panels of monoclonal antibodies (mAbs) and polyclonal antisera indicated that the three viruses were antigenically divergent, although they were all H3N8 subtype related to other equine 2 -viruses isolated between 1963 and 1987. Results of virus protein synthesis investigated by pulse-chase experiments showed heterogeneity among the proteins of the ribonucleoprotein complex and the haemagglutinin glycoproteins, which were not cleaved in tissue culture. The results of this study indicate that equine H3 HAs have evolved by a process of evolutionary divergence and mutational changes, as confirmed by genetic analysis in another study. The results also showed that antigenic variation occurs among equine H3 influenza viruses and that H3 viruses with antigenically different HA molecules could co-circulate in equine populations.
Ključne riječi
H3 influenza viruses; antigenicity analysis; equine; Nigeria
Hrčak ID:
96737
URI
Datum izdavanja:
19.6.2000.
Posjeta: 940 *