Izvorni znanstveni članak
Changes of Acid Phosphatase Activity in Various Clinical Stages of Oral Lichen Planus. II. Changes of Acid Phosphatase Activity in Subepithelial Mononuclear Cell Infiltrate
Marinka Mravak-Stipetić
; Zavod za bolesti usta Stomatološkog fakulteta Sveučilišta u Zagrebu, Zagreb, Hrvatska
Ahmed Pirkić
; Klinički zavod za patologiju “Prof. dr. Ljudevit Jurak” Kliničke bolnice “Sestre milosrdnice” Stomatološkog fakulteta u Zagrebu
Milutin Dobrenić
; Zavod za bolesti usta Stomatološkog fakulteta Sveučilišta u Zagrebu, Zagreb, Hrvatska
Ana Cekić-Arambašin
; Zavod za bolesti usta Stomatološkog fakulteta Sveučilišta u Zagrebu, Zagreb, Hrvatska
Sažetak
Thirty-three biopsy specimens from lesions of oral lichen planus (OLP) and 18 from leukoplakia (LPL) were examined for the study of acid phosphatase activity in subepithelial mononuclear cell infiltrate (MCI). Results showed a high level of activity in all mononuclear cells of OLP in inflammation as well as in hyperkeratosis. In LPL, a decrease in both the number of active lymphocytes and number of active macrophages was observed in inflammation, while active dendritic macrophages were not found. Acid phosphatase activity was expressed in all mononuclear cells of OLP, distributed sub-basally and in focal accumulations deeper in lamina propria, depending on the evolutional stage of the disease, which was not observed in LPL. Interesting was the finding of active dendritic macrophages in moderate and severe hyperkeratosis in LPL, contrary to the finding in OLP. This suggested different pathogenesis of hyperkeratotic process in the two diseases. Different distribution and hystoenzymatic activity in mononuclear cells of the examined lesions provided a more detailed insight into their role and differences in the pathogenesis of OLP and LPL.
Ključne riječi
oral lichen planus; leukoplakia; subepithelial mononuclear cell infiltrate; enzyme histochemistry; acid phosphatase
Hrčak ID:
99124
URI
Datum izdavanja:
15.6.1995.
Posjeta: 1.170 *