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Small-surface Charge-coupled Device for Radiosotope Probing

John F Fritz ; Private practice both in dentistry and in pharamcy, Louisville, Kentucky, USA
Allan G. Farman ; School of Dentistry, The University of Louisville, Louisville, Kentucky 40292, USA
Taeko T. Farman ; School of Dentistry, The University of Louisville, Louisville, Kentucky 40292, USA
Francis Mouyen ; Toulouse, France

Puni tekst: engleski pdf 7.927 Kb

str. 237-241

preuzimanja: 438



Objective: Radionuclide imaging is used to determine the distribution
of radioactively labelled radiopharmaceuticals following application
to establish the anatomy affected by a variety of neoplastic, metabolic
and inflammatory conditions. This is accomplished through recording
radioactive emissions using a gamma camera of a SPECT system,
neither of which provides high resolution. The purpose o f this investigation was to determine whether a charge-coupled device designed for intraoral radiography could be modified to detect high energy emissions made by radiopharmaceutical agents. Methods: A RadioVisioGraphy (RVG) 32000 (Trophy Radiologie, Vincennes, France) with an unsealed sensor was employed so that the scintillator could be varied. The system was further modified to be activated by a CCX timer (Trophy Radiologie, Vincennes, France) disassociated from an x-ray generator. Radionuclides tested included 125I, 133Xe, 99mTc, 1311 and 60Co. Images were attempted of metallic test objects of known outline. Images were stored in a PC-compatible computer using the proprietary software provided by Trophy Radiologie for digital dental radiography. Results: Discernible images were found with Tc-99m calibrated at 900-925 mCi. No deterioration o f the sensor occured despite the high energy of the source, hence the tungsten glass fiberoptic prism of the RVG 32000 was effective in protecting the change-coupled device (CCD) from radiation damage.
Conclusions: While further studies are needed, this preliminary study shows that there is a potential fo r using small surface CCDs for the detection of radiopharmaceuticals and, hence, to better localize the distribution of deposition within small cavities such as the mouth.

Ključne riječi

charge-coupled device, nuclear medicine, radiopharmaceuticals

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Podaci na drugim jezicima: hrvatski

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