Skoči na glavni sadržaj

Collegium antropologicum, Vol. 37 No. 1, 2013.

Izvorni znanstveni članak

Mometasone Furoate and Nasal Vascularisation in Allergic Patients

Milodar Kujundzic ; University of Rijeka, Rijeka University Hospital Center, Department of Otorhinolaryngology, Head and Neck Surgery, Rijeka,
Emina Babarovic ; University of Rijeka, School of Medicine, Department of Pathology, Rijeka, Croatia
Marija Petkovic ; University of Rijeka, Rijeka University Hospital Center, Department of Radiotherapy and Oncology, Rijeka, Croatia
Ira Pavlovic-Ruzic ; University of Rijeka, Rijeka University Hospital Center, Department of Radiotherapy and Oncology, Rijeka, Croatia
Miran Coklo ; University of Rijeka, School of Medicine, Department of Forensic Medicine, Rijeka, Croatia
Gordana Zamolo orcid id orcid.org/0000-0002-7702-1876 ; University of Rijeka, School of Medicine, Department of Pathology, Rijeka, Croatia

Puni tekst: engleski pdf 169 Kb

str. 127-130

preuzimanja: 394

citiraj

Sažetak

Angiogenesis, the growth and proliferation of new blood vessels, is important in a variety of pathophysiological processes. However the role of angiogenesis in allergic rhinitis has not been well studied. Hence, the aim of this study was to compare the vascularisation of the nasal mucous membrane of non-allergic, non-treated allergic and allergic patients treated with mometasone furoate. A small piece of the nasal mucous membrane was taken from the frontal pole of the
lower nasal shell from 90 patients. The patients were divided in three groups, each containing 30 patients. First group of patients (GP1) had a negative inhalatory allergen test, patients in second group (GP2) had positive test but were not under treatment and the third group of patients (GP3) had positive results with the same test and were treated with mometasone furoate for 15 days before analysis. Immunhistochemical staining with anti-CD31 and VEGF-C was performed. Vascular phase was determined by using length density. Differences in expression of CD31 and VEGF-C were compared
using one-way ANOVA and Tukey HSD post-hoc tests. Significantly lower values of CD31 and VEGF-C expression were observed in GP1 in compare with GP2 and GP3 (p<0.001, p=0.013, respectively). In GP3 the microvessel density was significantly lower than in GP2 (p<0.001), but higher than in GP1. Our results demonstrated that 15-day treatment with mometasone furoate results in a significant reduction of the density of vascular parameters in allergic patients.

Ključne riječi

vascularisation; nasal mucous membrane; allergy; mometasone furoate

Hrčak ID:

99529

URI

https://hrcak.srce.hr/99529

Datum izdavanja:

3.4.2013.

Posjeta: 1.284 *