Veterinarski arhiv, Vol. 83 No. 2, 2013.
Izvorni znanstveni članak
The influence of experimental hypothyroidism on hepatic and renal function in rams in an arid tropical environment.
Koshal K. Gupta
; Department of Veterinary Biochemistry, College of Veterinary and Animal Sciences, Bikaner, India
Anil Gattani
; Department of Veterinary Biochemistry, Bihar Veterinary College, Patna, India
Anil Moolchandani
; Department of Veterinary Biochemistry, College of Veterinary and Animal Sciences, Bikaner, India
Meenaxi Sareen
; Department of Veterinary Biochemistry, College of Veterinary and Animal Sciences, Bikaner, India
Sažetak
Crop residues are rich in thiourea content, on account of the indiscriminate use of thiourea as a fertilizer. It is interesting to investigate the impact of thiorea feeding on liver and kidney functions in adult sheep. Experimental hypothyroidism was induced by per os feeding of thiourea to nine adult Marwari rams. Prior to the start of the trial, plasma levels of thyroxin (T4), thyroid stimulating hormone (TSH), alkaline Phosphatase (ALP), Aspartate aminotransferase (AST), alanine amminotransferase (ALT), glucose, protein, A/G ratio, BUN and creatinine were assessed to establish control values. The clinical profile of the rams and evaluation of the above parameters were conducted on Days 3, 5 and 7 post thiourea feeding. At the end of the experiment a decrease in respiration, heart rate, temperature and feed intake were observed. A significant fall in T4 and glucose was observed on day 7, whereas a significant increase in TSH, ALP, AST and ALT were observed. The elevation in protein, BUN and creatinine concentrations was not much significant. The altered hormone profile revealed the hypofunction of the thyroid gland. The increased concentration of enzymes revealed bile duct hyperplasia, damage to hepatocytes and the biliary network. Further, a shift in metabolic profile suggested low energy intake and depressed growth. In conclusion, thiourea feeding induces hypothyroidism, generalized oxygen starvation at tissue level and disturbs hepatic and renal functions.
Ključne riječi
thiourea; hypothyroidism; thyroxine; aspartate aminotransferase; alanine aminotransferase; alkaline phosphatase
Hrčak ID:
99793
URI
Datum izdavanja:
28.3.2013.
Posjeta: 1.037 *