Pregledni rad

Pathogenesis of osteoarthritis

Stipe Kosor ; Medicinski fakultet Sveučilišta u Zagrebu

Sažetak

Osteoarhtitis was once commonly called a degenerative joint disease. Recent findings justify the suffix “itis”. The most important proinflammatory cytokines are IL-1β and TNF, as they stimulate the production of other cytokines such as IL-8, IL-6, LIP, and its own production, leading to accelerated damage of articular tissues. Inflammatory mediators such as reactive oxygen and nitrogen species play an important role in pathogenesis of OA. Genetic predisposition and older age make the joint more susceptible, while
obesity, with increased load on weight-bearing joints and increased production of adipokines, affects on the development of OA. Although the complexity of the process makes it difficult to determine which factors are most important, it all contributes to paving the way towards developing new therapeutic possibilities.

Ključne riječi

osteoarthritis; pathogenesis; inflammatory mediators

Hrčak ID:

100545

URI

https://hrcak.srce.hr/100545

Datum izdavanja:

23.4.2013.

Podaci na drugim jezicima: hrvatski

Posjeta: 3.576 *