Medica Jadertina, Vol. 43 No. 1-2, 2013.
Stručni rad
The safety and efficacy of proton pump inhibitors in laryngopharyngeal reflux treatment
Marija Odak
; Opća bolnica Šibenik
Željka Roje
; ¸KBC Split, Klinika za bolesti uha, nosa i grla s kirurgijom glave i vrata, Medicinski fakultet Sveučilišta u Splitu, Katedra za otorinolaringologiju
Mirnes Selimović
; Dom zdravlja Šibenik-Dežurstvo Primošten
Goran Račić
; KBC Split, Klinika za bolesti uha, nosa i grla s kirurgijom glave i vrata, Medicinski fakultet Sveučilišta u Splitu
Sažetak
Objective: To examine the safety and efficacy of proton pump inhibitors in the treatment of laryngopharyngeal reflux.
Materials and methods: The research was conducted from October 2009 to May 2011 at the Clinic of Ear, Nose and Throat Diseases with Head and Neck Surgery, Split Clinical Hospital, Split, Croatia. The
examinees were patients with one or more symptoms of laryngopharyngeal reflux: hoarseness, coughing, feeling throat lumps, chronic cleaning and burning throat and snoring. Indirect laryngo-scopes examination and 24-hour pH-metry before and after three months proton pump inhibitors therapy was performed on
examinees.
Hypothesis: Treatment of laryngopharyngeal reflux with proton pump inhibitors (Pantoprazole) for a period of three months effectively reduces the subjective and objective parameters of disease without
side effects.
Results: After completing pantoprazole therapy, the reflux finding score was statistically significantly lower (12 vs. 10) (p < 0.05). The average pH value of the upper oesophageal sphincter was statistically
significantly higher after therapy (5.41 vs. 6.14) (p < 0.05) and pH during sleep (5.12 vs. 5.76) (p < 0.05) and vigilance (5.75 vs. 6.12) (p < 0.05). The most important of subjective symptoms are the complete disappearance of cough (19 vs. 0) (p < 0.05) and reduction of chronic throat clearing (7 vs. 3) (p < 0.05).
Among the objective clinical findings, only the posterior commissure hypertrophy following PPI treatment showed statistically significant reduction in the severity of the findings (10 vs. 2) (p < 0.05).
Conclusion: Proton pump inhibitors applied twice daily at a dose of 20 mg in a period of three months are safe and effective in the treatment of laryngopharyngeal reflux. Treatment success was confirmed by the disappearance and reduction of individual symptoms, improving indirectly laryngoscopic finding and reducing the acidity level of the upper oesophageal sphincter in vigilance and sleeping.
Ključne riječi
laringopharyngeal reflux; proton pump inhibitors; 24-hour pH-monitoring
Hrčak ID:
100548
URI
Datum izdavanja:
23.4.2013.
Posjeta: 2.667 *