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Correlation between HLA-DR Antigens and Oral Lichen Planus

Marina Ognjenović ; Dom zdravlja »Dr. Petar Vitezica«, Split, Hrvatska
Ana Cekić-Arambašin ; Zavod za bolesti usta, Stomatološki fakultet Sveučilišta u u Zagrebu, Zagreb, Hrvatska


Puni tekst: hrvatski pdf 5.052 Kb

str. 251-254

preuzimanja: 708

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Sažetak

Oral lichen planus (OLP) is a chronic disease associated with various metabolic disturbances of the body as well as with immunologic disorders related to HLA-antigens. The aim of this study conducted in the patient population in Croatia was to determine whether OLP was related to some specific HLA-DR type, due to its association with metabolic disturbances, especially those affecting the metabolism of carbohydrates. Fifty-three patients with clinically and histopathologically diagnosed OLP were examined and subjected to HLA-DR antigen typing, and compared to 1039 normal subjects in whom HLA typing was done for the purpose o f paternity suit. Typing o f the tissue tolerance antigen o f DR type was performed on a suspension o f solid B lymphocytes, with the addition o f DR antigen causing lysis o f lymphocytes. Results showed a statistically significant correlation between O LP and HLA-DRw9. Difference in HLA-DR3 and H LA-DR5 values found in OLP patients and control subjects was not statistically significant.

Ključne riječi

HLA-DR antigens, oral lichen planus

Hrčak ID:

100768

URI

https://hrcak.srce.hr/100768

Podaci na drugim jezicima: hrvatski

Posjeta: 1.052 *