Pregledni rad

Role of HER2 signaling pathway in breast cancer: biology, detection and therapeutical implications

NATALIJA DEDIĆ PLAVETIĆ orcid.org/0000-0003-0505-4756 ; Department of Medical Oncology, Division of Oncology, University Hospital Center and Zagreb Medical School, Zagreb, Croatia
ANA KULIĆ ; Department of Pathophysiology, Division of Oncology, University Hospital Center, Zagreb, Croatia
DAMIR VRBANEC ; 1_Department of Medical Oncology, Division of Oncology, University Hospital Center and Zagreb Medical School, Zagreb, Croatia; 2_Department of Pathophysiology, Division of Oncology, University Hospital Center, Zagreb, Croatia

Sažetak

Human epidermal growth factor receptor 2 (HER2), a member of the
ErbB family of transmembrane receptor tyrosine kinases, is amplified in 20–30% of invasive breast cancers. HER2 amplification is associated with metastasis and reduced survival. Therapies targeting HER2 receptor are effective in adjuvant treatment and in metastatic disease. Several agents have demonstrated promising activity in HER2 metastatic breast cancer, either as monotherapy or in combination therapy, including the tyrosine-kinase inhibitors lapatinib and neratinib, and the anti-HER2 monoclonal antibodies trastuzumab, pertuzumab and trastuzumab-DM1/T-DM1/. Despite the improvement in overall survival with the addition of HER2-targeted agents to chemotherapy,many patients do not benefit fromthe agents because of inherent resistance. In addition,many patients who achive an initial response eventually acquire drug resistance. Several mechanism of resistance have been described, including mutations in other signalling pathways, expression of a truncated form of HER2, receptor crosstalk, and autophagy.

Ključne riječi

Hrčak ID:

101255

URI

https://hrcak.srce.hr/101255

Datum izdavanja:

30.9.2012.

Posjeta: 6.618 *