Pregledni rad

"Double hit" lymphoma or secondary MYC translocation lymphoma?

PETRA KORAĆ ; Faculty of Science, Department of Molecular Biology, University of Zagreb, Zagreb, Croatia
SNJEŽANA DOTLIĆ ; Department of Pathology and Cytology, University Hospital Center Zagreb, Zagreb, Croatia
MARA DOMINIS ; Medical School Zagreb, University of Zagreb, Šalata 3, 10000 Zagreb, Croatia

Sažetak

Chromosomal translocations that juxtapose different genes required for proliferation and differentiation are frequently associatedwith hematologic neoplasms. A term "double hit" lymphoma refers to a group of mature B-cell malignancies that harbor MYC rearrangement accompanied with another translocation commonly found in lymphomas (i.e. IGH/BCL2). A complex karyotype with multiple abnormalities and very aggressive course of disease are additional characteristics of this group. The response to currently available treatment regimens is unsatisfying, thus reported overall survival of these patients is usually very short. Today, the precise mechanisms
of "double hit" lymphoma development are still unclear, although several possible pathways have been proposed in the literature. Similar oncogenic chain of events was also observed in another common hematological malignant neoplasm – multiple myeloma. MYC translocation as a secondary pathogenic phenomenon has been demonstrated in multiple myeloma, as well as complex cytogenetics and very aggressive course of the disease. Therefore, secondary translocation involving MYC gene might be a potential marker of aggressive neoplasms emerging from different cells of origin, and
united under the umbrella of "MYC-plus" malignancies. That concept
might, in the future, result in a novel therapy, targeting this distinct, but not unique cytogenetic aberration.

Ključne riječi

Hrčak ID:

101263

URI

https://hrcak.srce.hr/101263

Datum izdavanja:

30.9.2012.

Posjeta: 2.399 *