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Risk factors for severe acute lower respiratory infections in children – a systematic review and meta-analysis

Stewart Jackson ; Centre for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, UK
Kyle H. Mathews ; Centre for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, UK
Dražen Pulanić ; Clinical Hospital Centre Zagreb, Zagreb, Croatia, and Faculty of Medicine Osijek, J.J. Strossmayer University of Osijek, Osijek, Croatia
Rachel Falconer ; Centre for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, UK
Igor Rudan ; Centre for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, UK
Harry Campbell ; Centre for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, UK
Harish Nair ; Public Health Foundation of India, New Delhi, India


Puni tekst: engleski pdf 456 Kb

str. 110-121

preuzimanja: 4.068

citiraj


Sažetak

Aim To identify the risk factors in children under five years
of age for severe acute lower respiratory infections (ALRI),
which are the leading cause of child mortality.
Methods We performed a systematic review of published
literature available in the public domain. We conducted
a quality assessment of all eligible studies according to
GRADE criteria and performed a meta-analysis to report the
odds ratios for all risk factors identified in these studies.
Results We identified 36 studies that investigated 19 risk
factors for severe ALRI. Of these, 7 risk factors were significantly
associated with severe ALRI in a consistent manner
across studies, with the following meta-analysis estimates
of odds ratios (with 95% confidence intervals): low birth
weight 3.18 (1.02-9.90), lack of exclusive breastfeeding 2.34
(1.42-3.88), crowding – more than 7 persons per household
1.96 (1.53-2.52), exposure to indoor air pollution 1.57
(1.06-2.31), incomplete immunization 1.83 (1.32-2.52), undernutrition
– weight-for-age less than 2 standard deviations
4.47 (2.10-9.49), and HIV infection 4.15 (2.57-9.74).
Conclusion This study highlights the role of the above
seven risk factors in the development of severe pneumonia
in under-five children. In addition, it emphasizes the
need for further studies investigating other potential risk
factors. Since these risk factors are potentially preventable,
health policies targeted at reducing their prevalence provide
a basis for decreasing the burden of childhood pneumonia.

Ključne riječi

Hrčak ID:

102805

URI

https://hrcak.srce.hr/102805

Datum izdavanja:

15.4.2013.

Posjeta: 4.573 *