Crtice

A Novel Route to the Niementowski Reaction

Mazaahir Kidwai ; Department of Chemistry, University of Delhi, Delhi-110007, India
Shweta Rastogi ; Department of Chemistry, University of Delhi, Delhi-110007, India
Richa Mohan ; Department of Chemistry, University of Delhi, Delhi-110007, India
Ruby ; Department of Chemistry, University of Delhi, Delhi-110007, India

Sažetak

The Niementowski reaction has been extended to synthesize 3-substituted/2,3-disubstituted-4(3H)quinazolinones instead of the 2-substituted derivatives. The methodology is environmentally benign and completely eliminates the need of solvent from the reaction. Neat reactants were cyclocondensed under microwaves to afford, in good yield, the desired product in less irradiation time as compared to the classical technique. The reaction time was reduced from hours to minutes along with yield enhancement. The rate enhancement and high yield are attributed to the coupling of solvent-free conditions with microwaves.

Ključne riječi

Niementowski reaction; microwave irradiation (MWI); neat reaction conditions; quinazolinone; environmentally benign

Hrčak ID:

103200

URI

https://hrcak.srce.hr/103200

Datum izdavanja:

28.11.2003.

Posjeta: 2.918 *