Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2013.54.257
The risk of false inclusion of a relative in parentage testing – an in silico population study
James Chun-I Lee
; Department of Forensic Medicine College of Medicine, National Taiwan University, Taipei, Taiwan, ROC
Li-Chin Tsai
; Department of Forensic Science, Central Police University, Taoyuan, Taiwan ROC
Pao-Ching Chu
; Department of Forensic Medicine College of Medicine, National Taiwan University, Taipei, Taiwan, ROC
Yen-Yang Lin
; Department of Forensic Medicine College of Medicine, National Taiwan University, Taipei, Taiwan, ROC
Chun-Yen Lin
; Institute of Forensic Medicine, Ministry of Justice, New Taipei City, Taiwan ROC
Tsun-Ying Huang
; Institute of Forensic Medicine, Ministry of Justice, New Taipei City, Taiwan ROC
Yu-Jen Yu
; Institute of Forensic Medicine, Ministry of Justice, New Taipei City, Taiwan ROC
Adrian Linacre
; School of Biological Sciences, Flinders University, Adelaide, Australia
Hsing-Mei Hsieh
; Department of Forensic Science, Central Police University, Taoyuan, Taiwan ROC
Sažetak
Aim To investigate the potential of false inclusion of a
close genetic relative in paternity testing by using computer
generated families.
Methods 10 000 computer-simulated families over three
generations were generated based on genotypes using 15
short tandem repeat loci. These data were used in assessing
the probability of inclusion or exclusion of paternity
when the father is actually a sibling, grandparent, uncle,
half sibling, cousin, or a random male. Further, we considered
a duo case where the mother’s DNA type was not
available and a trio case including the mother’s profile.
Results The data showed that the duo scenario had the
highest and lowest false inclusion rates when considering
a sibling (19.03 ± 0.77%) and a cousin (0.51 ± 0.14%) as
the father, respectively; and the rate when considering a
random male was much lower (0.04 ± 0.04%). The situation
altered slightly with a trio case where the highest rate
(0.56 ± 0.15%) occurred when a paternal uncle was considered
as the father, and the lowest rate (0.03 ± 0.03%) occurred
when a cousin was considered as the father. We also
report on the distribution of the numbers for non-conformity
(non-matching loci) where the father is a close genetic
relative.
Conclusions The results highlight the risk of false inclusion
in parentage testing. These data provide a valuable
reference when incorporating either a mutation in the father’s
DNA type or if a close relative is included as being
the father; particularly when there are varying numbers of
non-matching loci.
Ključne riječi
Hrčak ID:
104768
URI
Datum izdavanja:
15.6.2013.
Posjeta: 1.380 *