Psychiatria Danubina, Vol. 24. No. 2., 2012.
Izvorni znanstveni članak
DOUBLE-BLIND PLACEBO-CONTROLLED RANDOMIZED EFFICACY AND SAFETY TRIAL OF ADD-ON TREATMENT OF DIMEBON PLUS RISPERIDONE IN SCHIZOPHRENIC PATIENTS DURING TRANSITION FROM ACUTE PSYCHOTIC EPISODE TO REMISSION
Margarita A. Morozova
orcid.org/0000-0002-7847-2716
; Laboratory of psychopharmacology, Mental Health Research Center of Russian Academy of Medical Sciences, Moscow, Russia
Allan G. Beniashvili
; Laboratory of psychopharmacology, Mental Health Research Center of Russian Academy of Medical Sciences, Moscow, Russia
Taisiya A. Lepilkina
; Laboratory of psychopharmacology, Mental Health Research Center of Russian Academy of Medical Sciences, Moscow, Russia
Georgiy E. Rupchev
; Laboratory of psychopharmacology, Mental Health Research Center of Russian Academy of Medical Sciences, Moscow, Russia
Sažetak
Background: There is evidence that blockade of 5-HT 6 receptors can improve cognitive dysfunction in schizophrenic patients. A
number of antagonists of 5-HT6 receptors are in development as cognitive enhancers. One of the agents with relatively strong 5-HT6
activity is dimebon. We tested the hypothesis that this 5-HT6 antagonist administered in the early stage of stabilization after an acute
episode can improve both neurocognitive and clinical symptoms in schizophrenia. A phase II study of dimebon as add-on to
risperidone therapy was conducted.
Subjects and methods: 56 male subjects with paranoid schizophrenia were included in the study. All the patients demonstrated
therapeutic response to risperidone as treatment of the acute psychotic episode. After 4 weeks of stability patients were randomized
into two groups with placebo or dimebon add-on treatment in a 1 to 1 ratio for 8 weeks. PANSS, CGI-S, CSDS and NSA-16 were
used as clinical measures of symptom severity. Different aspects of memory, psycho-motor coordination and executive functioning
were assessed with a battery of cognitive tests. Clinical and cognitive assessment was performed twice: after a patient was
randomized and 2 months later.
Results: Severity of negative symptoms (by NSA-16) were significantly lower in the dimebon group then in the placebo group
(p=0.036). Patients in the dimebon group demonstrated improvement in more cognitive dimensions than patients in the placebo
group, including working memory, attention, psycho-motor coordination and planning.
Conclusion: Dimebon as add-on therapy to antipsychotic treatment in the period of stabilization after an acute episode can
improve some aspects of clinical and cognitive status in schizophrenic patients.
Ključne riječi
schizophrenia; cognitive dysfunction; dimebon; add-on treatment
Hrčak ID:
106218
URI
Datum izdavanja:
24.6.2012.
Posjeta: 1.398 *