Izvorni znanstveni članak

Correlations between radiographic, magnetic resonance imaging and histopathologic findings in experimentally ruptured cranial cruciate ligament joints in rabbits.

Behrooz Nikahval ; Department of Surgery and Radiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
Seifollah N. Dehghani ; Department of Surgery and Radiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
Mohammad H. Bagheri ; Department of Radiology, Namazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Sara Pakbaz ; Department of Pathology, Chamran Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Maryam Mansourian ; Razi Vaccine and Serum Reasearch Institute, Shiraz, Iran
Nader Tanideh ; Stem cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Davood Mehrabani ; Stem cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Masoud Alirezaei ; School of Veterinary Medicine, University of Lorestan, Khorram Abad, Iran

Sažetak

Experimental osteoarthritis (OA) was induced in the knee joints of rabbits and the trend of changes were compared by radiography, Magnetic Resonance Imaging (MRI) and histopathology. Twenty rabbits were randomly divided into two equal groups based on short (30 days) and long-term (180 days) follow ups. In half of the animals in each group (n = 5) OA was induced by sectioning the cranial cruciate ligament and in the other half, only arthrotomy was performed as a sham operation. Radiography and MRI were carried out on days 0 and 30 in the group of short term studies, and on days 0, 90 and 180 in the other group. Histopathological examinations were performed on day 30 in the short-term group after the animals had been sacrificed and in the other group on day 180. The slope of changes over the course of the study between all 3 methods and the grade of changes, were both highest in histopathology, and then in MRI and radiology respectively. The slope of changes was 0.01 for histopathology, 0.009 for MRI and 0.004 for radiology. The ratios of slopes, when compare to each other, were as follows: His./MRI = 1.1, His./Rad. = 2.5, MRI/Rad. = 2.2. Comparison of MRI with radiology revealed that radiology would not show signs of OA when the MRI grade is less than a grade of 0.27. Comparing both imaging techniques with histopathology showed that whenever the histopathological grade was below 0.22, radiology would not show signs of OA involvement, while MRI was capable of showing signs of OA involvement whenever it was more than 0.018 on histopathological grade.

Ključne riječi

radiography; magnetic resonance imaging; histopathology; ruptured cranial cruciate ligament; rabbit

Hrčak ID:

108378

URI

https://hrcak.srce.hr/108378

Datum izdavanja:

27.9.2013.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.074 *