Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2013.54.346
Multiple presence of prothrombotic risk factors in Croatian children with arterial ischemic stroke and transient ischemic attack
Jasna Leniček Krleža
orcid.org/0000-0002-2554-4034
; Department of Laboratory Diagnostics, Children’s Hospital Zagreb, Zagreb, Croatia
Vlasta Đuranović
; Department of Neuropediatrics Children’s Hospital Zagreb, Zagreb,Croatia
Ana Bronić
; Department of Laboratory Diagnostics, University Hospital Center “Sestre milosrdnice,” Hospital for Traumatology, Zagreb, Croatia
Desiree Coen Herak
; Clinical Institute of Laboratory Diagnosis, University School of Medicine and University Hospital Center Zagreb, Zagreb, Croatia
Vlatka Mejaški-Bošnjak
; Department of Neuropediatrics Children’s Hospital Zagreb, Zagreb,Croatia
Renata Zadro
; Clinical Institute of Laboratory Diagnosis, University School of Medicine and University Hospital Center Zagreb, Zagreb, Croatia
Sažetak
Aim To determine the frequency of inherited and acquired
prothrombotic risk factors in children with arterial ischemic
stroke (AIS) and transient ischemic attacks (TIA) in Croatia.
Methods We investigated 14 prothrombotic risk factors
using blood samples from 124 children with AIS or TIA and
42 healthy children. Prothrombotic risk factors were classified
into five groups: natural coagulation inhibitors (antithrombin,
protein C, protein S), blood coagulation factors
(FV Leiden and FII 20210), homocysteine, lipid and lipoprotein
profile (lipoprotein (a), triglycerides, total, high- and
low-density lipoprotein), and antiphospholipid antibodies
(lupus anticoagulant, anticardiolipin, and antiphosphatidylserine
antibodies).
Results The most common prothrombotic risk factor was
elevated lipoprotein (a), which was identified in about 31%
of patients and in 24% of controls. Natural coagulation inhibitors
were decreased in about 19% of patients, but not
in controls. Pathological values of homocysteine, blood
coagulation factor polymorphisms, and antiphospholipid
antibodies were found in similar frequencies in all groups.
Fourteen children with AIS and TIA (11.3%) and no children
from the control group had three or more investigated risk
factors.
Conclusion The presence of multiple prothrombotic risk
factors in children with cerebrovascular disorder suggests
that a combination of risk factors rather than individual risk
factors could contribute to cerebrovascular disorders in
children.
Ključne riječi
Hrčak ID:
108673
URI
Datum izdavanja:
15.8.2013.
Posjeta: 960 *