Stručni rad

Human protein C concentrate in a patient with meningitis and bleeding as a complication of treatment with recombinant activated protein C

MARTINA CRIVELLARI ; Department of Anesthesia and Intensive Care, San Raffaele Scientific Institute, Milano, Italy
SERGIO COLOMBO ; Department of Anesthesia and Intensive Care, San Raffaele Scientific Institute, Milano, Italy
MILENA MUCCI ; Department of Anesthesia and Intensive Care, San Raffaele Scientific Institute, Milano, Italy
VALENTINA PLUMARI ; Department of Anesthesia and Intensive Care, San Raffaele Scientific Institute, Milano, Italy
PAOLO SILVANI ; Department of Anesthesia and Intensive Care, San Raffaele Scientific Institute, Milano, Italy
ALBERTO ZANGRILLO ; Department of Anesthesia and Intensive Care, San Raffaele Scientific Institute, Milano, Italy
PATRIZIA DELLA VALLE ; Coagulation Service & Thrombosis Research Unit, San Raffaele Scientific Institute, Via Olgettina 60 Milano, 20132 Italy
ARMANDO D’ANGELO ; Coagulation Service & Thrombosis Research Unit, San Raffaele Scientific Institute, Via Olgettina 60 Milano, 20132 Italy

Sažetak

Some case reports suggest that protein C zymogen supplementation may improve the outcome of patients with congenital or acquired protein C deficiency, such as sepsis-induced purpura fulminans. We describe the case report of a patient suffering from meningitis who developed a bleeding complication after recombinant human activated protein C administration and was successfully treated without any further bleeding complication with protein C concentrate. Protein C concentrate can be considered in adult patients with meningitis, even if at risk or in the presence of bleeding.

Ključne riječi

sepsis; purpura fulminans; protein C; bleeding

Hrčak ID:

108800

URI

https://hrcak.srce.hr/108800

Datum izdavanja:

1.4.2013.

Posjeta: 1.807 *