Acta Pharmaceutica, Vol. 63 No. 4, 2013.
Kratko priopćenje
https://doi.org/10.2478/acph-2013-0035
In vitro dissolution and in vivo gamma-scintigraphic evaluation of press-coated salbutamol sulfate tablet
WEI LI
; Shenyang Pharmaceutical University, Shenyang 110016, Liaoning Province, China
CAI-HONG SHI
; Shenyang Pharmaceutical University, Shenyang 110016, Liaoning Province, China
YI-LING SHENG
; Shenyang Pharmaceutical University, Shenyang 110016, Liaoning Province, China
PING CUI
; The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
YU-QING ZHAO
; Shenyang Pharmaceutical University, Shenyang 110016, Liaoning Province, China
XIANG-RONG ZHANG
; Shenyang Pharmaceutical University, Shenyang 110016, Liaoning Province, China
Sažetak
The aim of this study was to investigate the in vitro and in vivo performance of salbutamol sulfate press-coated tablets for delayed release. The in vitro release behavior of press-coated tablets with the outer layer of PEG 6000/Eudragit S100 blends (2:1) in pH 1.2 (0.1 mol L–1 HCl) and then pH 6.8 buffer solution was examined. Morphological change of the press-coated tablet during in vitro release was recorded with a digital camera. Release of salbutamol sulfate from press-coated tablets was less than 5 % before 3 h and was completed after 8 h in pH 6.8 phosphate buffer solution. In vivo gamma scintigraphy study carried out on healthy men indicated that the designed system released the drug in lower parts of the GI tract after a lag time of 5 hours. The results showed the capability of the system of achieving delayed release of the drug in both in vitro and in vivo gamma scintigraphy studies.
Ključne riječi
salbutamol sulfate; press-coated tablet; PEG 6000-Eudragit S100 blends; dissolution; gamma scintigraphy
Hrčak ID:
110462
URI
Datum izdavanja:
31.12.2013.
Posjeta: 1.363 *