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Pregledni rad

https://doi.org/10.2478/10004-1254-64-2013-2414

Immunological Aspects and Anti-Amyloid Strategy for Alzheimer’s Dementia

Rajka M. Liščić ; Institute for Medical Research and Occupational Health, Zagreb, Croatia


Puni tekst: engleski pdf 125 Kb

verzije

str. 603-607

preuzimanja: 783

citiraj


Sažetak

Alzheimer’s dementia (AD) is the most common form of dementia among the elderly, accounting for at least two-thirds of all dementia cases. It represents a costly burden, since its global prevalence is estimated at 24 million cases. Amyloid beta or Aβ plaques and neurofibrillary tangles define AD pathologically but do not fully explain it, because dementia may also be caused by inflammation resulting in neuronal, axonal synaptic loss and dysfunction. An important component of AD pathophysiology are amyloid plaques surrounded by activated microglia, cytokines, and complement components, suggesting inflammation. In the diagnosis of AD, cerebrospinal fluid markers, especially in vivo amyloid measurements, contribute to an accurate assessment of AD pathology and differential diagnosis. Aβ levels are a very good marker for the presence of amyloid deposits in the brain, while total tau and phosphorylated tau are useful for the detection of neurodegeneration. The implementation of anti-amyloid therapy and other disease-modifying interventions may have immense clinical impact ifinitiated at an early or presymptomatic stage of AD, before significant brain damage occurs. This paper briefly reviews the abovementioned topics and provides recommendations for future studies.

Ključne riječi

Alzheimer’s disease; amyloid-β (Aβ) plaques; anti-amyloid therapy; inflammation; microglia

Hrčak ID:

111792

URI

https://hrcak.srce.hr/111792

Datum izdavanja:

6.12.2013.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.777 *