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https://doi.org/10.2478/acph-2014-0004

Pitavastatin-attenuated cardiac dysfunction in mice with dilated cardiomyopathy via regulation of myocardial calcium handling proteins

WEI HU ; Department of Intensive Care Unit, The First People’s Hospital of Hangzhou, Nanjing Medical University, Hangzhou, 310006, Zhejiang, China
WEN-BING JIANG ; Department of Cardiology, Wenzhou Third People’s Hospital, Wenzhou, 325000, Zhejiang, China


Puni tekst: engleski pdf 359 Kb

str. 105-105

preuzimanja: 494

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Sažetak

C57BL/6 mice with dilated cardiomyopathy (DCM) were randomly divided to receive placebo or pitavastatin at a dose of 1 or 3 mg kg–1 d–1. After 8 weeks of treatment, mice with dilated cardiomyopathy developed serious cardiac dysfunction characterized by significantly enhanced left ventricular end-diastolic diameter (LVIDd), decreased left ventricular ejection fraction (LVEF) as well as left ventricular short axis fractional shortening (LVFS), accompanied with enlarged cardiomyocytes, and increased plasma levels of N-terminal pro-B type natriuretic peptide (NT-proBNP) and plasma angiotensin II (AngII) concentration. Moreover, myocardium sarcoplasmic reticulum Ca2+ pump (SERCA-2) activity was decreased. The ratio of phosphorylated phospholamban (PLB) to total PLB decreased significantly with the down-regulation of SERCA-2a and ryanodine receptor (RyR2) expression. Pitavastatin was found to ameliorate the cardiac dysfunction in mice with dilated cardiomyopathy by reversing the changes of the ratios of phosphorylated PLB to total PLB, SERCA-2a and RyR2 via reducing the plasma AngII concentration, and the expressions of myocardium angiotensin II type 1 receptor (AT1R) and protein kinase C (PKC)β2. The possible underlying mechanism might be the regulation of myocardial AT1R-PKCβ2-Ca2+ handling proteins.

Ključne riječi

pitavastatin, dilated cardiomyopathy, calcium handling proteins, renin-angiotensin system, protein kinase Cβ2

Hrčak ID:

113583

URI

https://hrcak.srce.hr/113583

Posjeta: 891 *