Paediatria Croatica, Vol. 58 No. 1, 2014.
Pregledni rad
https://doi.org/10.13112/PC.2014.9
Indeterminate result of interferon-gamma release assay in a child: review of literature with illustrative case
Ivan Pavić
orcid.org/0000-0003-2670-2003
; Klinika za pedijatriju, Klinika za dječje bolesti Zagreb, Zagreb
Dorian Tješić Drinković
; Klinika za pedijatriju, KBC Zagreb, Zagreb
Jasna Čepin Bogović
; Klinika za pedijatriju, Klinika za dječje bolesti Zagreb, Zagreb
Slavica Dodig
; Dječja bolnica Srebrnjak
Sažetak
Interferon-gamma release assays (IGRAs) have off ered signifi cant progress in the detection of M. tuberculosis infection. In addition
to obtaining negative or positive results of IGRAs, there is a possibility of getting indeterminate results. An indeterminate test result
indicates situations where it is not possible to determine the state of M. tuberculosis infection. Interpretation and accurate follow-up
of children with indeterminate test results pose diagnostic challenges for clinicians. The aim of the present review is to show an
illustrative case of a 15-month-old boy with indeterminate result of the QuantiFERON-TB Gold In-Tube test (QFT-GIT, Cellestis Ltd.,
Carnegie, Australia) during pneumonia, to point out the problems associated with getting indeterminate results. Follow-up test
result after recovery was negative. QFT-GIT should preferably be performed upon resolution of acute infl ammation with standardization
of preanalytical and analytical factors in order to avoid indeterminate results. Furthermore, evidence-based guidelines
on the optimal follow-up of children with indeterminate results will be important as IGRAs use becomes increasingly widespread.
Ključne riječi
interferon-gama release tests; Mycobacterium tuberculosis; infant
Hrčak ID:
120003
URI
Datum izdavanja:
24.3.2014.
Posjeta: 672 *