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Collegium antropologicum, Vol. 38 No. 1, 2014.

Original scientific paper

Comparison Between Clinical Significance of Serum Proinflammatory Protein Interleukin-6 and Classic Tumor Markers Total PSA, Free PSA and Free/Total PSA Prior to Prostate Biopsy

Nevenka Miličević ; 1 »J. J. Strossmayer« University, University Hospital Centre Osijek, Reanimatology and Intensive Care Unit, Department of Anesthesiology, Osijek, Croatia
Milanka Mrčela ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Department of Pathology and Forensic Medicine, Osijek, Croatia
Ivana Lukić ; »J. J. Strossmayer« University, School of Medicine, Osijek, Croatia
Sanja Mandić ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Department of Clinical Laboratory Diagnostics, Osijek, Croatia
Vesna Horvat ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Department of Clinical Laboratory Diagnostics, Osijek, Croatia
Josip Galić ; »J. J. Strossmayer« University, University Hospital Centre Osijek, Clinic of Urology, Osijek, Croatia

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Abstract

The aim of the study was to clarify whether serum levels of proinflammatory cytokine interleukin-6 (IL-6) could be a useful marker in prostate diseases. Serum IL-6 was determined prior to prostate biopsy procedure in 82 patients with prostate adenocarcinoma (PCa), 25 patients with benign prostatic hyperplasia (BPH), 24 patients with high-grade prostatic intraepithelial neoplasia (PIN) and 17 patients with chronic prostatitis. Serum IL-6 levels were compared with total PSA (tPSA), free PSA (fPSA) and the free/total ratio (f/tPSA) serum levels. Statistically significant difference was not found in serum IL-6 levels among the four groups (p=0.088). However, the patients with poorly differentiated PCa with Gleason score (GS) 4+3=7 and >7 had significantly higher serum IL-6 levels than the patients with moderately differentiated PCa with GS 3+4=7 and <7 (p=0.007). The findings suggest that serum IL-6 level might be a potentially useful marker for poorly differentiated PCa.

Keywords

interleukin-6; serum levels; prostate biopsy; prostate-specific antigen; Gleason score

Hrčak ID:

120866

URI

https://hrcak.srce.hr/120866

Publication date:

31.3.2014.

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