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Immunonopatogenesis of Chronic Periapical Lesions

Greta Škaljac-Staudt
Nada Galić
Marina Katunarić
Ivana Ciglar
Davor Katanec

Puni tekst: hrvatski pdf 72 Kb


str. 121-126

preuzimanja: 1.041


Puni tekst: engleski pdf 66 Kb


str. 127-131

preuzimanja: 1.144



Chronic periapical lesion is a result of the mutual activity of microbiota in the root canal and multilateral response of the host to infection. Nonspecific, acute and chronic inflammations, including humoral and cellular immunological responses, participate in the occurrence, development and perpetuation of these lesions. Biopsy samples of periapical tissue were taken by surgical procedure in 34 patients, with the object of verifying immunoglobulin classes G, A and M. The study involved determination of total proteins by Lowry’s method. Concentrations of IgG, IgA and IgM were determined by the method of radial immunodiffusion. Their correct amount was obtained by placing them in relation to the verified amount of total proteins. The study revealed different percentages of the share of immunoglobulins, classes G, A and M, and diversity in their values.
IgG was found in 100% of cases, IgA in 76% and IgM in 44%. Mean value of the quantity of IgG amounted to 385.2 mg/g protein, ranging in value from 27.3 to 826.0 mg/g protein, IgA 51.0 mg/g protein, ranging from 0 to 336.8 mg/g protein, and IgM 20.3 mg/g, ranging from 0 to156.2 mg/g protein.
The results obtained on the basis of this study indicate the local synthesis of immunoglobulins in chronic periapical lesions, and the involvement of nonspecific inflammatory and specific immunological reactions, which together are responsible for the pathogenesis of these lesions.

Ključne riječi

periapical lesion; immunoglobulin G; immunoglobulin A; immunoglobulin M

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Podaci na drugim jezicima: hrvatski

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