Veterinarski arhiv, Vol. 84 No. 3, 2014.
Izvorni znanstveni članak
Pharmacokinetics and dosage regimen of florfenicol in co-administration with paracetamol in cross bred calves.
Vinod K. Dumka
; Department of Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India
Inderdeep Singh
; Department of Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India
Sažetak
The pharmacokinetics of florfenicol were investigated in cross-bred calves treated with a single intravenous administration (20 mg/kg) following a single intramuscular injection of paracetamol (50 mg/kg). The concentration of florfenicol in the plasma was estimated by microbiological assay technique, using E. coli as the test organism. The drug reached a maximum concentration of 31.5 ± 1.45 μg/mL in the plasma at 1 min, and this rapidly declined to 15.6 ± 0.46 μg/mL at 30 min. It was detected in the plasma above the minimum inhibitory concentration up to 12 h after administration. The disposition pattern of florfenicol followed the two-compartment open model. Florfenicol was fairly distributed from the blood to the tissue compartment as evidenced by the moderate values of the distribution coefficient, (2.23 ± 0.18 per h) and the ratio of K12 /K21 (0.82 ± 0.1). The values of AUC and Vdarea were 54.8 ± 1.51 g/mL.h and 1.5 ± 0.06 L/kg respectively. The elimination half-life, MRT and total body clearance were 2.84 ± 0.07 h, 3.61 ± 0.06 h and 0.37 ± 0.01 L/kg/h, respectively. Florfenicol at a dose of 20 mg/kg body weight IV at 12 h interval is sufficient to maintain T>MIC above 80% for bacteria with MIC values 1.0 μg/mL. The favourable pharmacokinetic profile of florfenicol with rapid distribution, high AUC, large Vdarea and 12 h dosing interval suggest that florfenicol may be an appropriate antibacterial when prescribed with paracetamol in cross-bred calves.
Ključne riječi
calves; dosage; florfenicol; paracetamol; pharmaacokinetics
Hrčak ID:
121944
URI
Datum izdavanja:
28.5.2014.
Posjeta: 2.183 *