Stručni rad

Laboratory diagnostics of ANCA-vasculitis

Ilza Salamunić ; Odjel za medicinsko laboratorijsku dijagnostiku, Klinički bolnički centar Split, Split, Hrvatska
Dušanka Martinović Kaliterna ; Odjel za kliničku imunologiju i reumatologiju, Klinika za unutarnje bolesti, Klinički bolnički centar Split, Split, Hrvatska

Sažetak

The antineutrophil cytoplasmic antibody (ANCA) are associated with distinct forms of primary small vessel vasculitides, collectively reffered to as ANCA-associated vasculitis (AAV). ANCA were originally identified by IIF. Importantly, however, only ANCA directed to PR3 (PR3-ANCA) or MPO (MPO-ANCA) are relevant for the diagnosis AAV, there is international consensus that ANCA should be detected by a combination of IIF and antigen-specific assays, i.e. detection of PR3 and MPO-ANCA. Several novel technologies have become available for antigen-specific ANCA detection.

Ključne riječi

ANCA; vasculitis; clinical laboratory diagnosis

Hrčak ID:

123337

URI

https://hrcak.srce.hr/123337

Datum izdavanja:

17.10.2013.

Podaci na drugim jezicima: hrvatski

Posjeta: 4.249 *