Stručni rad

Anti-neutrophil cytoplasmic antibodies (ANCA) associated vasculitides

Dušanka Martinović Kaliterna ; Odjel za kliničku imunologiju i reumatologiju, Klinika za unutarnje bolesti, Klinički bolnički centar Split, Split, Hrvatska
Ivanka Marinović ; Odjel za fizikalnu medicinu, rehabilitaciju i reumatologiju, Klinički bolnički centar Split, Split, Hrvatska
Ilza Salamunić ; Odjel za medicinsko laboratorijsku dijagnostiku, Klinički bolnički centar Split, Split, Hrvatska

Sažetak

The anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitides are a group of uncommon diseases characterised by inflammatory cell infiltration and necrosis of blood vessel walls. ANCA there has been considerable progress towards understanding their pathogenesis. This results in endothelial activation with increased transmigration and adherence of neutrophils to vessel walls. Specific for granulomatosis with polyangiitis are nasal or oral inflammation and development of oral ulcers and purulent or bloody nasal discharge. The chest radiograph usually showed the presence of nodules or fixed infiltrates. Microscopic polyangiitis affects the smallest blood vessels and may also affect medium-sized vessels, demonstrates the tropism for the kidneys - glomerulonephritis and lungs - pulmonary capillaritis. The characteristic features of eosinophilic granulomatosis with polyangiitis are asthma, eosinophilia in peripheral blood, sinusitis and pulmonary infiltrates which may be transient, than mononeuritis multiplex. It is important to differentiate ANCA vasculitis and syndromes that may mimic them, particularly infection, malignancy and connective tissue disease.

Ključne riječi

vasculitis; anti-neutrophil cytoplasmic antibody; blood vessel; inflammation; necrosis; polyangiitis

Hrčak ID:

123339

URI

https://hrcak.srce.hr/123339

Datum izdavanja:

17.10.2013.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.181 *